Scutellaria Baicalensis

Cararthron®: Active Ingredients

Cararthron®is a new improved formula of a naturally-derived product for arthritis relief. It contains a blend of Scutellaria baicalensis and Acacia catechu, both of which have been used traditionally in oriental and ayurvedic medicine for their anti-inflammatory properties.

The active ingredients of these plant extracts are natural anti-inflammatory agents called flavonoids and flavans.1 Scutellaria baicalensis contains the flavonoids baicalin, baicalein and wogonin, and Acacia catechu contains the flavonoids catechin and epicatechin. They work by inhibiting all 3 enzymatic pathways involved in inflammation (COX-1, COX-2 and LOX),2 and they also help slow the breakdown of cartilage in the joints.3,4

This blend of plant extracts has undergone extensive preclinical and clinical testing. Recent randomised double-blind clinical trials confirm the encouraging results from preclinical studies.5,6 This naturally-derived product helps to reduce the symptoms of arthritis such as pain and stiffness, and increasing mobility.5,6

 

Scutellaria Baicalensis

It is one of the 50 fundamental herbs used in traditional Chinese medicine, where it has the name huáng qín (Chinese: 黄芩).

Scutellaria baicalensis Georgi contains wogonin, a flavone which was found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines.

Acacia Catechu

Acacia catechu contains the flavonoids epicatechin and catcechin, and has been used in traditional ayurvedic medicine practices. Widely used in treating skin related disorders, it is also a good anti-inflammatory herb, and offers relief from swelling.

Show/Hide References

  1. Lim H, et al. Inhibition of chronic skin inflammation by topical anti-inflammatory flavonoid preparation, Ato Formula. Arch Pharm Res 2006; 29: 503-7.
  2. Burnett BP, et al. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food 2007; 10: 442-51.
  3. Adcocks C, et al. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J Nutr 2002; 132: 241-6.
  4. Hsieh CJ, et al. Baicalein inhibits IL-1- and TNF- -induced inflammatory cytokine production from human mast cells via regulation of the NF- B pathway. Clin Mol Allergy 2007; 5:5.
  5. Levy R, et al. Safety and efficacy of flavocoxide compared with naproxen in subjects with osteoarthritis of the knee: a pilot study. Osteoarthr Cartil 2008; 15(suppl B): B91.
  6. Sampalis JS, et al. Evaluation and comparison of the safety and efficacy of UP446 and celecoxib for the management of pain in patients with osteoarthritis. Data on file, Unigen Pharmaceuticals.
  7. "Scutellaria baicalensis information from NPGS/GRIN". USDA. Retrieved 2008-02-19.
  8. Hui KM, Huen MS, Wang HY, et al (November 2002). "Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi". Biochem. Pharmacol. 64 (9): 1415–24. PMID 12392823.
  9. http://www.ayushveda.com/herbs/acacia-catechu.htm